Fei, Haiyang published the artcileStereospecific Electrophilic Fluorocyclization of ¦Á,¦¢-Unsaturated Amides with Selectfluor, Application In Synthesis of 104-03-0, the publication is Organic Letters (2020), 22(7), 2651-2656, database is CAplus and MEDLINE.
An efficient fluorocyclization of ¦Á,¦¢-unsaturated amides I (R = Ph, 4-methoxyphenyl, 4-nitrophenyl, i-Pr, n-Bu, Bn; R1 = H, Me, Et, Ph, n-Pr, cyclopropyl, 4-methylphenyl, 4-nitrophenyl; R2 = H, Me, Et, Ph, octyl, etc.; R3 = H, Me, Et, Ph, n-Pr, cyclohexyl, etc.; R4 = Me, Et, i-Pr, t-Bu) through a formal halocyclization process is developed. The reaction proceeds under transition-metal-free conditions and leads to the formation of fluorinated oxazolidine-2,4-diones II with excellent regio- and diastereoselectivity. The evaluation of the reaction mechanism based on preliminary experiments and d. functional theory calculations suggests that a synergetic syn-oxo-fluorination occurs and is followed by an anti-oxo substitution reaction. The reaction opens a new window in the field of stereospecific fluorofunctionalization.
Organic Letters published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, Application In Synthesis of 104-03-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia