Acta Pharmaceutica Sinica B published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, SDS of cas: 71989-31-6.
Hu, Kuan published the artcileWhole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors, SDS of cas: 71989-31-6, the publication is Acta Pharmaceutica Sinica B (2022), 12(3), 1363-1376, database is CAplus and MEDLINE.
Peptides that are composed of dextrorotary (D)-amino acids have gained increasing attention as a potential therapeutic class. However, our understanding of the in vivo fate of D-peptides is limited. This highlights the need for whole-body, quant. tracking of D-peptides to better understand how they interact with the living body. Here, we used mouse models to track the movement of a programmed death-ligand 1 (PD-L1)-targeting D-dodecapeptide antagonist (DPA) using positron emission tomog. (PET). More specifically, we profiled the metabolic routes of [64Cu]DPA and investigated the tumor engagement of [64Cu/68Ga]DPA in mouse models. Our results revealed that intact [64Cu/68Ga]DPA was primarily eliminated by the kidneys and had a notable accumulation in tumors. Moreover, a single dose of [64Cu]DPA effectively delayed tumor growth and improved the survival of mice. Collectively, these results not only deepen our knowledge of the in vivo fate of D-peptides, but also underscore the utility of D-peptides as radiopharmaceuticals.
Acta Pharmaceutica Sinica B published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, SDS of cas: 71989-31-6.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia