Le Vaillant, Franck published the artcileRoom temperature decarboxylative cyanation of carboxylic acids using photoredox catalysis and cyanobenziodoxolones: a divergent mechanism compared to alkynylation, Synthetic Route of 1798-04-5, the publication is Chemical Science (2017), 8(3), 1790-1800, database is CAplus and MEDLINE.
The one-step conversion of aliphatic carboxylic acids to the corresponding nitriles was accomplished via the merger of visible light mediated photoredox and s (CBX) reagents. The reaction proceeded in high yields with natural and non-natural ¦Á-amino and ¦Á-oxy acids, affording a broad scope of nitriles with excellent tolerance of the substituents in the ¦Á position. The direct cyanation of dipeptides and drug precursors was also achieved. The mechanism of the decarboxylative cyanation was investigated both computationally and exptl. and compared with the previously developed alkynylation reaction. Alkynylation was found to favor direct radical addition, whereas further oxidation by CBX to a carbocation and cyanide addition appeared more favorable for cyanation. A concerted mechanism was proposed for the reaction of radicals with EBX reagents, in contrast to the usually assumed addition elimination process.
Chemical Science published new progress about 1798-04-5. 1798-04-5 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(4-(tert-Butyl)phenoxy)acetic acid, and the molecular formula is C12H16O3, Synthetic Route of 1798-04-5.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia