Shen, Li published the artcileNovel hybrids from lamellarin D and combretastatin A4 as cytotoxic agents, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is European Journal of Medicinal Chemistry (2010), 45(1), 11-18, database is CAplus and MEDLINE.
A new series of hybrids of lamellarin D and combretastatin A4, 1,2-diphenyl-5,6-dihydropyrrolo[2,1-a]isoquinolines, was designed as cytotoxic agents based on principles of combination in medicinal chem. and taking the parent compounds’ different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids, e.g. I, were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.
European Journal of Medicinal Chemistry published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C15H14BNO4S, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia