Wang, Xu-Dong published the artcileSynthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agent, Name: 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Bioorganic & Medicinal Chemistry (2015), 23(15), 4860-4865, database is CAplus and MEDLINE.
3-Arylfuran-2(5H)-one derivatives show good antibacterial activity and were determined as tyrosyl-tRNA synthetase (TyrRS) inhibitors. In a systematic medicinal chem. exploration, we demonstrated chem. opportunities to treat infections caused by Helicobacter pylori. Twenty 3-arylfuran-2(5H)-ones were synthesized and evaluated for anti-H. pylori, antioxidant and anti-urease activities which are closely interconnected with H. pylori infection. The results displayed that some of the compounds show excellent antioxidant activity, and good anti-H. pylori and urease inhibitory activities. Out of these compounds, 3-(3-methylphenyl)furan-2(5H)-one (I) showed the most potent antioxidant activity (IC50 = 8.2 ¦ÌM) and good anti-H. pylori activity (MIC50 = 2.6 ¦Ìg/mL), and it can be used as a good candidate for discovering novel anti-gastric ulcer agent.
Bioorganic & Medicinal Chemistry published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C8H11BO2, Name: 2-(3-(Benzyloxy)phenyl)acetic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia