Fang, Ze-Yu published the artcileDesign, Synthesis and Molecular Docking of Novel Quinazolinone Hydrazide Derivatives as EGFR Inhibitors, HPLC of Formula: 118-90-1, the publication is Chemistry & Biodiversity (2022), 19(6), e202200189, database is CAplus and MEDLINE.
A series of novel quinazolinone hydrazide derivatives were designed and synthesized as EGFR inhibitors. The results indicated that most of the aimed compounds had potential anti-tumor cell proliferation and EGFR inhibitory activities. In the comprehensive anal. of all the tested compounds, the target compound 9c showed the best anti-tumor cell proliferation activity, (IC50=1.31 ¦ÌM for MCF-7, IC50=1.89 ¦ÌM for HepG2, IC50=2.10 ¦ÌM for SGC), and IC50=0.59 ¦ÌM for the EGFR inhibitory activity. Docking results showed that compound 9c could ideally insert the active site and interact with the critical amino acid residues (Val702, Lys721, Met769, Asp831) in the active site.
Chemistry & Biodiversity published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, HPLC of Formula: 118-90-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia