Jakhmola, Vikash published the artcileSynthesis and in-vivo activity of some antihypertensive agent based on pyridazine scaffold design, Related Products of catalysis-chemistry, the publication is International Journal of Pharmaceutical Sciences and Research (2022), 13(2), 786-792, database is CAplus.
The main objective presents research work to synthesize, characterization, and in-vivo evaluation of Pyridazine derivatives To study the different synthesized derivatives by using different anal. parameters like IR, Mass, and NMR anal. And also find out the antihypertensive activity. The studies on the hydralazine group drugs led to the synthesis of many Pyridazine derivatives with a wide activity spectrum on the cardiovascular system. Pyridazine derivatives, a class of compounds containing the N-N bond, exhibit a wide range of pharmacol. activities such as antidepressant, antihypertensive and cardiotonic, etc. Some 7-phenyl-3, 4, 8, 9-tetrahydro-2H-pyridazino [1, 6-a] [1, 3, 5] triazin-2-imine were synthesized by reacting 6-Ph substituted 2, 3, 4, 5-Tetrahydro pyridazin-3-one with cyclic secondary amine under Mannich reaction conditions. The total seven compounds (vj1-vj7) were synthesized under Mannich reaction conditions. All the synthesized derivatives were selected for evaluation of antihypertensive activities by a noninvasive method using Tail Cuff method. Most of the compounds showed good antihypertensive activity. Few compounds like vj4, vj5, and vj6 were found to show a highly significant reduction in mean arterial blood pressure but at a higher dose in comparison to standard drugs like proponolol and hydralazine. The substituted pyridazine derivatives discovered in this study may provide valuable therapeutic intervention for the treatment of hypertension.
International Journal of Pharmaceutical Sciences and Research published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia