Jiang, Yongwei published the artcileSynthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2011), 21(15), 4471-4475, database is CAplus and MEDLINE.
On the basis of the active site of lanosterol 14¦Á-demethylase from Candida albicans (CACYP51), a series of 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-1,2,4-triazol-5(4H)-one derivatives I (R = 4-F, 2-F, 4-Cl, 3-Cl, 2,4-Cl2, 3-Br, 2-Br, 4-MeO, 3-MeO, 4-OCF3, 4-Me, 3-Me, 2-Me, 3,4-Me2, 2,4-Me2, 4-nPr, 4-Bu, 4-pentyl, 4-hexyl, 4-tBu, 4-iPr) and II (R = 4-F, 3-F, 2-F, 4-Cl, 3,4-Cl2, 4-Br, 3-Br, 4-Me, 2,3-Me2, 4-MeO, 3,4-(MeO)2,2,4-(MeO)2, 4-NO2, 3-NO2, 2-NO2, 3-CN) were synthesized as fluconazole analogs. Results of the preliminary antifungal tests against eight human pathogenic fungi in vitro showed that these compounds exhibited activities to some extent, and some displayed excellent antifungal activities against C. albicans than reference drug fluconazole. Flexible mol. docking was used to analyze the structure-activity relationships (SARs) of the target compounds The designed compounds interact with CACYP51 through hydrophobic, van der Waals and hydrogen-bonding interactions.
Bioorganic & Medicinal Chemistry Letters published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia