Purchase, Rupert published the artcileThe purification of triethylenetetramine and its dihydrochloride for the treatment of Wilson’s disease, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Chemical Research (2005), 233-235, database is CAplus.
A method for the purification of triethylenetetramine and its dihydrochloride for use in the treatment of Wilson’s disease is reported. Thus, tech. grade triethylenetetramine (I) 1.18 Kg was mixed with water 262 mL and seeded with a few crystals of I hydrate; the precipitated I hydrate was collected and washed with THF and di-Et ether; the I hydrate was slurried with water 500 mL, cooled and treated with HCl to pH 7.8; evaporation of the aqueous solution (below 60¡ãC, 12 mmHg) and treatment of the residue with cold 95% ethanol afforded the dihydrochloride of I (854 g) containing a trace of impurity.
Journal of Chemical Research published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia