Wang, Siyao published the artcileSite-selective itaconation of complex peptides by photoredox catalysis, Recommanded Product: Fmoc-Pro-OH, the publication is Angewandte Chemie, International Edition (2022), 61(5), e202111388, database is CAplus and MEDLINE.
Site-selective peptide functionalization provides a straightforward and cost-effective access to diversify peptides for biol. studies. Among many existing non-invasive peptide conjugations methodologies, photoredox catalysis has emerged as one of the powerful approaches for site-specific manipulation on native peptides. Herein, we report a highly N-termini-specific method to rapidly access itaconated peptides and their derivatives through a combination of transamination and photoredox conditions. This strategy exploits the facile reactivity of peptidyl-dihydropyridine in the complex peptide settings, complementing existing approaches for bioconjugations with excellent selectivity under mild conditions. Distinct from conventional methods, this method utilizes the highly reactive carbamoyl radical derived from a peptidyl-dihydropyridine. In addition, this itaconated peptide can be further functionalized as a Michael acceptor to access the corresponding peptide-protein conjugate.
Angewandte Chemie, International Edition published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C8H6ClF3, Recommanded Product: Fmoc-Pro-OH.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia