Wang, Youliang published the artcileIntramolecular Insertions into Unactivated C(sp3)-H Bonds by Oxidatively Generated ¦Â-Diketone-¦Á-Gold Carbenes: Synthesis of Cyclopentanones, HPLC of Formula: 1237588-12-3, the publication is Journal of the American Chemical Society (2015), 137(16), 5316-5319, database is CAplus and MEDLINE.
Generation of reactive ¦Á-oxo gold carbene intermediates via gold-catalyzed oxidation of alkynes has become an increasing versatile strategy of replacing hazardous diazo carbonyl compounds with benign and readily available alkynes in the development of efficient synthetic methods. However, one of the hallmarks of metal carbene/carbenoid chem., i.e., insertion into an unactivated C(sp3)-H bond, has not be realized. This study reveals for the first time that this highly valuable transformation can be readily realized intramolecularly by oxidatively generated ¦Â-diketone-¦Á-gold carbenes using ynones as substrates. Substrate conformation control via the Thorpe-Ingold effect is the key design feature that enables generally good to excellent efficiencies, and synthetically versatile cyclopentanones including spiro-, bridged, and fused bicyclic ones can be readily accessed.
Journal of the American Chemical Society published new progress about 1237588-12-3. 1237588-12-3 belongs to catalysis-chemistry, auxiliary class Mono-phosphine Ligands, name is 4-(2-(Di(adamantan-1-yl)phosphino)phenyl)morpholine, and the molecular formula is C10H12O5, HPLC of Formula: 1237588-12-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia