Zheng, Suhua published the artcileMagnesium-Promoted Reductive Carboxylation of Aryl Vinyl Ketones: Synthesis of ¦Ã-Keto Carboxylic Acids, COA of Formula: C10H10O3, the publication is Journal of Organic Chemistry (2022), 87(11), 7342-7349, database is CAplus and MEDLINE.
Direct reductive carboxylation of aryl vinyl ketones under the atm. of carbon dioxide led to the selective formation of ¦Ã-keto carboxylic acids ArC(O)CH2CHR1C(O)OH [Ar = Ph, 2-MeC6H4,4-FC6H4, etc.; R1 = Me, Et, ph] in 38-86% yields. The reaction was characterized by the carbon-carbon bond formation of carbon dioxide at the ¦Â-position of enone, with the use of magnesium turnings that can be easily handled as the reducing agent and the eco-friendly reaction conditions such as no pressuring, no lower or higher reaction temperature, and short reaction time. This protocol showed a wide substrate scope and provided a useful and convenient alternative to access biol. important ¦Ã-keto carboxylic acids which then converted to esters of ¦Ã-keto carboxylic acids under the typical esterification conditions.
Journal of Organic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C9H4F6O, COA of Formula: C10H10O3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia