Katz, Michael G. published the artcileMolecular cardiac surgery with recirculating delivery (MCARD): procedure and vector transfer, Quality Control of 140-28-3, the publication is Methods in Molecular Biology (New York, NY, United States) (2017), 271-289, database is CAplus and MEDLINE.
Despite progress in clin. treatment, cardiovascular diseases are still the leading cause of morbidity and mortality worldwide. Therefore, novel therapeutic approaches are needed, targeting the underlying mol. mechanisms of disease with improved outcomes for patients. Gene therapy is one of the most promising fields for the development of new treatments for the advanced stages of cardiovascular diseases. The establishment of clin. relevant methods of gene transfer remains one of the principal limitations on the effectiveness of gene therapy. Recently, there have been significant advances in direct and transvascular gene delivery methods. The ideal gene transfer method should be explored in clin. relevant large animal models of heart disease to evaluate the roles of specific mol. pathways in disease pathogenesis. Characteristics of the optimal technique for gene delivery include low morbidity, an increased myocardial transcapillary gradient, esxtended vector residence time in the myocytes, and the exclusion of residual vector from the systemic circulation after delivery to minimize collateral expression and immune response. Here we describe myocardial gene transfer techniques with mol. cardiac surgery with recirculating delivery in a large animal model of post ischemic heart failure.
Methods in Molecular Biology (New York, NY, United States) published new progress about 140-28-3. 140-28-3 belongs to catalysis-chemistry, auxiliary class Benzenes, name is N1,N2-Dibenzylethane-1,2-diamine, and the molecular formula is C16H20N2, Quality Control of 140-28-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia