Leong, Sze Wei published the artcileSynthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Molecules (2014), 19(10), 16058-16081, 24 pp., database is CAplus and MEDLINE.
A series of ninety-seven diarylpentanoid derivatives I (R = H, 4-Cl, 4-Br, 5-OCH3, 3,5-(OCH3)2, 4-OCH3, 4,6-(Cl)2; Ar = 3,4,5-trimethoxyphenyl, 2-chlorophenyl, 1-naphthyl, 2-furyl, 5-chloro-2-thienyl, etc.) were synthesized and evaluated for their anti-inflammatory activity through NO suppression assay using interferon gamma (IFN-¦Ã)/lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Some of the compounds I exhibited greater or similar NO inhibitory activity in comparison with curcumin (14.7 ¡À 0.2 ¦ÌM), notably compounds I (R = 4-Cl; Ar = 2,3-(OH)2-C6H3) and I (R = H; Ar = 2,3-(OH)2-C6H3), which demonstrated the most significant NO suppression activity with IC50 values of 4.9 ¡À 0.3 ¦ÌM and 9.6 ¡À 0.5 ¦ÌM, resp. A structure-activity relationship (SAR) study revealed that the presence of a hydroxyl group in both aromatic rings is critical for bioactivity of these mols. With the exception of the polyphenolic derivatives, low electron d. in ring-A and high electron d. in ring-B are important for enhancing NO inhibition. The pharmacophore mapping showed that hydroxyl substituents at both meta- and para-positions of ring-B could be the marker for highly active diarylpentanoid derivatives
Molecules published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia