Liang, Pei published the artcileEffects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation-dependence on GPR120, Application of Docosahexaenoic Acid, the publication is Prostate Cancer and Prostatic Diseases (2022), 25(3), 539-546, database is CAplus and MEDLINE.
Abstract: Background: The antiprostate cancer effects of dietary ¦Ø-3 fatty acids (FAs) were previously found to be dependent on host G-protein coupled receptor 120 (GPR120). Using an orthotopic tumor model and an ex-vivo model of bone marrow derived M2-like macrophages, we sought to determine if ¦Ø-3 FAs inhibit angiogenesis and activate T-cells, and if these effects are dependent on GPR120. Methods: Gausia luciferase labeled MycCaP prostate cancer cells (MycCaP-Gluc) were injected into the anterior prostate lobe of FVB mice. After established tumors were confirmed by blood luminescence, mice were fed an ¦Ø-3 or ¦Ø-6 diet. Five weeks after tumor injection, tumor weight, immune cell infiltration and markers of angiogenesis were determined An ex-vivo co-culture model of bone marrow derived M2-like macrophages from wild-type or GPR120 knockout mice with MycCap prostate cancer cells was used to determine if docosahexanoic acid (DHA, ¦Ø-3 FA) inhibition of angiogenesis and T-cell activation is dependent on macrophage GPR120. Results: Feeding an ¦Ø-3 diet significantly reduced orthotopic MycCaP-Gluc tumor growth relative to an ¦Ø-6 diet. Tumors from the ¦Ø-3 group had decreased M2-like macrophage infiltration and decreased expression of angiogenesis factors. DHA significantly inhibited M2 macrophage-induced endothelial tube formation and reversed M2 macrophage-induced T-cell suppression, and these DHA effects were mediated, in part, by M2 macrophage GPR120. Conclusion: Omega-3 FAs delayed orthotopic tumor growth, inhibited M2-like macrophage tumor infiltration, and inhibited M2-like macrophage-induced angiogenesis and T-cell suppression. Given the central role of M2-like macrophages in prostate cancer progression, GPR120-dependent ¦Ø-3 FA inhibition of M2-like macrophages may play an important role in prostate cancer therapeutics.
Prostate Cancer and Prostatic Diseases published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C22H32O2, Application of Docosahexaenoic Acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia