Chan, Leslie W. published the artcileSelective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization, Name: Dbco-maleimide, the publication is ACS Infectious Diseases (2021), 7(4), 721-732, database is CAplus and MEDLINE.
The drug-impermeable bacterial membrane in Gram-neg. pathogens limits antibiotic access to intracellular drug targets. To expand our rapidly waning antibiotic arsenal, one approach is to improve the intracellular delivery of drugs with historically poor accumulation in Gram-neg. bacteria. To do so, we engineered macromol. potentiators to permeabilize the Gram-neg. membrane to facilitate drug influx. Potentiators, known as WD40, were synthesized by grafting multiple copies of a cationic ¦Á-helical antimicrobial peptide, WLBU2, onto a dextran polymer scaffold. WD40 enabled drug uptake in the model pathogen P. aeruginosa, a capability that was not observed with unmodified WLBU2 peptide. WD40 was able to reduce min. inhibitory concentrations of a drug panel by up to 3 orders of magnitude. Hydrophobic and highly three-dimensional antibiotics exhibited the greatest potentiation. Antibiotic activity was potentiated in several clin. strains and resulted in sensitization of drug-resistant strains to rifampin, a drug not previously used for Gram-neg. infections.
ACS Infectious Diseases published new progress about 1395786-30-7. 1395786-30-7 belongs to catalysis-chemistry, auxiliary class Inhibitor, name is Dbco-maleimide, and the molecular formula is C25H21N3O4, Name: Dbco-maleimide.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia