Takahashi, Eiki published the artcileDiscovery of potent transient receptor potential vanilloid 1 antagonists: Design and synthesis of phenoxyacetamide derivatives, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(11), 3154-3156, database is CAplus and MEDLINE.
We aimed to discover a novel type of transient receptor potential vanilloid 1 (TRPV1) antagonist because such antagonists are possible drug candidates for treating various disorders. We modified the structure of hit compound I (human TRPV1 IC50 = 411 nM) and converted its pyrrolidino group to a (hydroxyethyl)methylamino group, which substantially improved inhibitory activity (II; human TRPV1 IC50 = 33 nM). In addition, II ameliorated bladder overactivity in rats in vivo.
Bioorganic & Medicinal Chemistry Letters published new progress about 163839-73-4. 163839-73-4 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Ether, name is 2-(4-(Trifluoromethyl)phenoxy)acetic acid, and the molecular formula is C8H6ClNO3S2, Application of 2-(4-(Trifluoromethyl)phenoxy)acetic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia