London, Clare published the artcileImidazopyridines: a novel class of hNav1.7 channel blockers, Related Products of catalysis-chemistry, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(5), 1696-1701, database is CAplus and MEDLINE.
A series of imidazopyridines were evaluated as potential sodium channel blockers for the treatment of neuropathic pain. Several members were identified with good hNav1.7 potency and excellent rat pharmacokinetic profiles. Compound I had good efficacy (52% and 41% reversal of allodynia at 2 and 4 h post-dose, resp.) in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain when dosed orally at 10 mg/kg.
Bioorganic & Medicinal Chemistry Letters published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia