Kraml, Michael published the artcileAgents affecting lipid metabolism. VIII. N,N’-Dibenzylethylenediamine, the key to a novel class of cholesterol biosynthesis inhibitors, Recommanded Product: Propane-1,3-diamine dihydrochloride, the publication is Journal of Medicinal Chemistry (1964), 7(4), 500-3, database is CAplus and MEDLINE.
cf. CA 58, 13786h; 60, 11242c. A number of mevalonic acid analogs and their N,N’-dibenzylethylenediamine (I) salts were tested for their effect on the incorporation of mevalonate-2-14C into cholesterol by rat liver homogenates. In contrast to the mevalonic acid analogs, their I salts exhibited an inhibitory property which was found to reside in I itself. The site of action of I is at the level of the conversion of 7-dehydrocholesterol to cholesterol. I was moderately effective in lowering serum sterols in hypercholesterolemic rats. Mol. modifications of I have resulted in compounds of increased potency, showing activity in vitro at a concentration of 10-8M.
Journal of Medicinal Chemistry published new progress about 10517-44-9. 10517-44-9 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is Propane-1,3-diamine dihydrochloride, and the molecular formula is C3H12Cl2N2, Recommanded Product: Propane-1,3-diamine dihydrochloride.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia