May, E. M. published the artcileA normal-phase high-performance liquid-chromatographic assay for aziridine residue in trientine dihydrochloride, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, the publication is Journal of Pharmaceutical and Biomedical Analysis (1987), 5(1), 65-70, database is CAplus and MEDLINE.
The aziridine??[151-56-4] residue in trientine (I) [112-24-3] (com. product), purified compound, and in I-HCl [38260-01-4] was determined by an indirect HPLC method on a LiChrosorb column (5-¦Ìm) with CH2Cl2-iso-PrOH (98.5:1.5) and UV detector at 260 and 410 nm. The compound was treated with Folin’s reagent in pH 11.9 phosphate buffer and the complex was chromatographed. The detection limit was 0.05 ppm. Seven com. samples of trientine were examined for the presence of aziridine by the above method, and no aziridine was detected in any of the samples. The method is applicable for basic drugs in general.
Journal of Pharmaceutical and Biomedical Analysis published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Recommanded Product: N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia