Asif, Mohammad published the artcileBrine Shrimp (Artemia salina) lethality bioassay of some 2-(Alkyl/Aryl)-6-phenyl-4,5-dihydropyridazin-3(2H)-one derivatives, Computed Properties of 2051-95-8, the publication is Indian Journal of Heterocyclic Chemistry (2021), 31(1), 57-61, database is CAplus.
A series of pyridazinone derivatives, 2-(alkyl/aryl)-6-phenyl-4,5-dihydropyridazin-3(2H)-ones I [R = Me, Et, Ph, Bn, etc.], was synthesized from 6-phenyl-4,5-dihydropyridazin-3(2H)-one. The 6-phenyl-4,5-dihydropyridazin-3(2H)-one was synthesized from benzoylpropionic acid. All the synthesized compounds were studied for their brine shrimp (artemia salina) lethality bioassay. The compounds 6-phenyl-4,5-dihydropyridazin-3(2H)-on, I and potassium dichromate (as reference drug) were tested at the dose level of 10, 20, and 30¦Ìg/mL. Compounds I [R = Et, n-Bu] exhibited potent brine shrimp lethality with LC50 values of 4.023¦Ìg and 4.20¦Ìg. Other compounds were also showed significant cytotoxic activity. The present study supported that brine shrimp bioassay was a simple, reliable, and suitable method for estimation of bioactivity of synthesized compounds and provided support for their use in medicine.
Indian Journal of Heterocyclic Chemistry published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Computed Properties of 2051-95-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia