Alghamdi, Saad published the artcileSynthesis, Characterization and Antimycobacterial Activity of Some Substituted Phenylpyridazinone Derivatives, Category: catalysis-chemistry, the publication is Pharmaceutical Chemistry Journal (2022), 55(12), 1367-1371, database is CAplus.
A series 6-phenyl-2-(substituted methyl)-dihydropyridazinone derivatives I [R = N-pyrrolidinyl, N-imidazolyl, N-morpholinyl, etc.] were synthesized using the interaction of 6-phenylpyridazinone with cyclic secondary amines such as pyrrolidine, 1H-Imidazole, morpholine, etc. by Mannich reaction and evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv strain by Microplate Alamar Blue Assay (MABA) method. The results indicated that I [R = N-imidazolyl, N-Phenothiazinyl] exhibited highest antimycobacterial activity. Other compounds I [R = N-pyrrolidinyl, N-triazolyl, N-piperidinyl, N-morpholinyl] showed less significant antimycobacterial activity. The most effective compounds I [R = N-imidazolyl, N-Phenothiazinyl] possessed MIC of 6.25¦Ìg/mL that was equal to that of reference drugs Streptomycin and Ciprofloxacin.
Pharmaceutical Chemistry Journal published new progress about 2051-95-8. 2051-95-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ketone, name is 3-Benzoylpropionicacid, and the molecular formula is C10H10O3, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia