Masuya, Takahiro published the artcileDiscovery of novel oestrogen receptor ¦Á agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors, Product Details of C13H10F2, the publication is Scientific Reports (2019), 9(1), 1-11, database is CAplus and MEDLINE.
Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chem. BPA interacts not only with estrogen receptors (ERs) but constitutive androstane receptor, pregnane X receptor, and estrogen-related receptor ¦Ã (ERR¦Ã); therefore, the bisphenol structure represents a privileged structure for the nuclear-receptor superfamily. Here, we screen 127 BPA-related compounds by competitive-binding assay using [3H]oestradiol and find that 20 compounds bind to ERa with high affinity. We confirm most of these as ERa agonists; however, four compounds, including bisphenol M and bisphenol P act as novel antagonists. These structures harbor three benzene rings in tandem with terminal hydroxy groups at para-positions, with this tandem tri-ring bisphenol structure representing a novel privileged structure for an ERa antagonist. Addnl., we perform an ab initio calculation and develop a new clipping method for halogen bonding or non-covalent interaction using DV-Xa evaluation for biomols.
Scientific Reports published new progress about 457-68-1. 457-68-1 belongs to catalysis-chemistry, auxiliary class Fluoride,Benzene, name is Bis(4-fluorophenyl)methane, and the molecular formula is C13H10F2, Product Details of C13H10F2.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia