Niwa, Atsushi published the artcileDevelopment of N,O-disubstituted hydroxylamines and N,N-disubstituted amines as insect juvenile hormone mimetics and the role of the nitrogenous function for activity, Computed Properties of 6084-58-8, the publication is Journal of Agricultural and Food Chemistry (1990), 38(2), 514-20, database is CAplus.
Insect juvenile hormone (JH) active N,O-disubstituted hydroxylamines were developed to examine the role of the nitrogenous function for high activity. They are O-alkyl-N-[(4-phenoxyphenoxy) and (4-benzylphenoxy)alkyl]hydroxylamines and reversely substituted N-alkyl-O-[(4-phenoxyphenoxy)alkyl]hydroxylamines. The activity against Culex?pipiens of the most potent member of each class was as high as that of the compounds known so far as the most active of JH mimics. When the overall length of the mols. is kept at the optimum, about 21 ?, suggested in earlier works, the compounds having a hydroxylamino N atom, rather than the O atom, at the ¦Ä-position from the central phenoxy O atom or at the 4-position (about 4.6 ?) from the alkyl end showed about 10 times higher activity than those having the N atom at position 1. The corresponding amine compounds showed this more clearly, but their activity was considerably lower than that of the hydroxylamines. The lower potency of the amines with pKa ¡Ö10 was attributed to their quaternization at physiol. pH, preventing going to or binding with the action site.
Journal of Agricultural and Food Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Computed Properties of 6084-58-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia