Sachin, Kalme published the artcileF-18 Labeling Protocol of Peptides Based on Chemically Orthogonal Strain-Promoted Cycloaddition under Physiologically Friendly Reaction Conditions, Quality Control of 17351-62-1, the publication is Bioconjugate Chemistry (2012), 23(8), 1680-1686, database is CAplus and MEDLINE.
We introduce the high-throughput synthesis of various 18F-labeled peptide tracers by a straightforward 18F-labeling protocol based on a chemo-orthogonal strain-promoted alkyne azide cycloaddition (SPAAC) using aza-dibenzocyclootyne-substituted peptides as precursors with 18F-azide synthon to develop peptide based positron emission tomog. (PET) mol. imaging probes. The SPAAC reaction and subsequent chemo-orthogonal purification reaction with azide resin proceeded quickly and selectively under physiol. friendly reaction conditions (i.e., toxic chem. reagents-free, aqueous medium, room temperature, and pH ¡Ö7), and provided four 18F-labeled tumor targetable bioactive peptides such as cyclic Arg-Gly-Asp (cRGD) peptide, bombesin (BBN), c-Met binding peptide (cMBP), and apoptosis targeting peptide (ApoPep) in high radiochem. yields as direct injectable solutions without any HPLC purification and/or formulation processes. In vitro binding assay and in vivo PET mol. imaging study using the 18F-labeled cRGD peptide also demonstrated a successful application of our 18F-labeling protocol.
Bioconjugate Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Quality Control of 17351-62-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia