Cho, Inha published the artcileSite-selective enzymatic C-H amidation for synthesis of diverse lactams, HPLC of Formula: 1293990-73-4, the publication is Science (Washington, DC, United States) (2019), 364(6440), 575-578, database is CAplus and MEDLINE.
A major challenge in carbon-hydrogen (C-H) bond functionalization is to have the catalyst control precisely where a reaction takes place. In this study, we report engineered cytochrome P 450 enzymes that perform unprecedented enantioselective C-H amidation reactions and control the site selectivity to divergently construct ¦Â-, ¦Ã-, and ¦Ä-lactams, completely overruling the inherent reactivities of the C-H bonds. The enzymes, expressed in Escherichia coli cells, accomplish this abiol. carbon-nitrogen bond formation via reactive iron-bound carbonyl nitrenes generated from nature-inspired acyl-protected hydroxamate precursors. This transformation is exceptionally efficient (up to 1,020,000 total turnovers) and selective (up to 25:1 regioselectivity and 97%, please refer to compound 2v enantiomeric excess), and can be performed easily on preparative scale.
Science (Washington, DC, United States) published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, HPLC of Formula: 1293990-73-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia