Cui, Shaoyu published the artcileDesign, synthesis and evaluation of wound healing activity for ¦Â-sitosterols derivatives as potent Na+/K+-ATPase inhibitors, Synthetic Route of 6084-58-8, the publication is Bioorganic Chemistry (2020), 103150, database is CAplus and MEDLINE.
¦Â-Sitosterols, is a common steroid that can be identified in a variety of plants and their efficacy in promoting wound healing has been demonstrated. Na+/K+-ATPase, more than a pump, its signal transduction function for involvement in cell growth regulation attracts widespread concern. The Na+/K+-ATPase/Src receptor complex can serve as a receptor involved in multiple signaling pathways including promoting wound healing pathways. To finding potent accelerating wound healing small mol., we choose the high inhibitory activity of Na+/K+-ATPase and non-cardiotoxic natural compound, ¦Â-sitosterol as the substrate. A series of ¦Â-sitosterol derivatives were designed, synthesized and evaluated as potential Na+/K+-ATPase inhibitors. Among them, some compounds showed improved inhibitory activity on Na+/K+-ATPase, with IC50 value of 3.0¦ÌM, 3.4¦ÌM, 2.2¦ÌM, which are more potent than ¦Â-sitosterol with IC50 7.6¦ÌM. Especially, compound I can induce cell proliferation, migration and soluble collagen production in L929 fibroblasts. Compared to model, compound I can accelerate wound healing in SD rats. Further studies indicated that I can activate the sarcoma (Src), uptake the protein kinase B (Akt), extracellular signal-regulated kinase (ERK) proteins expression in a concentration dependent manner. Finally, binding mode of compound I with Na+/K+-ATPase was studied, which provides insights into the determinants of potency and selectivity. These results proved ¦Â-stitosterol derivative 49 can serve as an effective inhibitor of Na+/K+-ATPase and potential candidate for accelerating wound healing agents.
Bioorganic Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Synthetic Route of 6084-58-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia