Nagy, Bence S. published the artcileN-Hydroxyphthalimide Catalyzed Aerobic Oxidation of Aldehydes under Continuous Flow Conditions, Synthetic Route of 118-90-1, the publication is Advanced Synthesis & Catalysis (2022), 364(12), 1998-2008, database is CAplus.
The efficacy of synthetic methodologies is based not only on potent chemistries but also on processing strategies that amplify reaction performance and overall safety. The N-hydroxyphtalimide-catalyzed aerobic oxidation of aldehydes is an environmentally reliable and inexpensive approach for the synthesis of valuable carboxylic acids. However, the reaction may lead to the accumulation of significant amounts of peracid in crude product mixtures thereby generating a considerable safety hazard. Also, in the case of deactivated substrates, long reaction times, high catalyst loading, and stoichiometric additives are required to promote oxidation Therefore, we developed a flow chem.-based process for N-hydroxyphtalimide-catalyzed aldehyde oxidations and exploited its benefits to minimize peracid buildup, thereby enhancing the process safety. By performing the aerobic oxidation of aldehydes under continuous flow conditions, chem. intensified and scalable carboxylic acid formation was obtained even in the reactions of deactivated substrates.
Advanced Synthesis & Catalysis published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Synthetic Route of 118-90-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia