Lupp, Amelie published the artcileA synopsis on different homologous series of fomocaine derivatives. In vitro interactions with the cytochrome P450 system, toxicity, and local anesthetic effects in rats., Application of 4-(Phenoxymethyl)benzoic acid, the publication is Arzneimittel Forschung (2007), 57(9), 562-567, database is CAplus.
Fomocaine (CAS 56583-43-6) is a basic ether-type local anesthetic used in dermatol. practice for surface anesthesia. For many years, modifications of the fomocaine mol. have been pursued, e.g. to improve its physicochem. properties and also in view of possible new (systemic) applications, e.g. in the treatment of migraine or as antiarrhythmic. The present paper provides a survey of the investigations undertaken with all the different series of fomocaine derivatives synthesized so far with respect to their in vitro interaction capacity at the cytochrome P 450 system, in vivo toxicity (LD50; paresis of the N. ischiadicus) and local anesthetic effects (conduction anesthesia at the N. ischiadicus; surface anesthesia of the cornea) in rats. The main objective of this systematic comparison of the effects of all these substances was to assess possible basic structure-activity relationships.
Arzneimittel Forschung published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C14H12O3, Application of 4-(Phenoxymethyl)benzoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia