Koronkiewicz, Miroslawa published the artcileProapoptotic effects of new pentabromobenzylisothiouronium salts in a human prostate adenocarcinoma cell line, Recommanded Product: 1,1-Dimethylthiourea, the publication is Acta Poloniae Pharmaceutica (2012), 69(6), 1325-1333, database is CAplus and MEDLINE.
Prostate cancer is the second most common cancer in elderly men worldwide and its incidence rate is rising continuously. Agents capable of inducing apoptosis in prostate cancer cells seem a promising approach to treat this malignancy. In this study we describe the synthesis of a number of novel N- and N,N’-substituted S-2,3,4,5,6-pentabrornobenzylisothiouronium bromides and their activity against the human prostate adenocarcinoma PC3 cell line. All the compounds produced changes in mitochondrial transmembrane potential and cell cycle progression, showed a cytostatic effect and induced apoptosis in the tested cancer line in a concentrationand time-dependent manner. The most effective compounds ZKK-3, ZKK-9 and ZKK-13 produced, at 20 ¦ÌM concentration, apoptosis in 42, 46, and 66% of the cells, resp., after 48 h incubation. Two selected S-2,3,4,5,6-pentabromobenzylisothiouronium bromides (ZKK-3, ZKK-9) showed also a synergic proapoptotic effect with the new casein kinase II inhibitor 2-(4-methylpiperazin-l-yl)-4,5,6,7-tetrabromo-1H-benzimidazole (TBIPIP) in the PC3 cell line.
Acta Poloniae Pharmaceutica published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Recommanded Product: 1,1-Dimethylthiourea.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia