Alsharif, Meshari A. published the artcilePharmacological Activities of Novel Chromene Derivatives as Calcium/Calmodulin Dependent Protein Kinase IV (CAMKIV) Inhibitors, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, the publication is ChemistrySelect (2020), 5(2), 498-505, database is CAplus.
A series of 3-nitro-2-phenyl-2H-chromenes I (R = 4-fluorophenyl, 2-nitrophenyl, naphthalen-1-yl, etc.; R1 = H, 3-OMe, 4-Me; R2 = 3-OMe, 4-F, 4-Cl, etc.) has been synthesized, characterized and tested for their inhibition potential and binding affinity with the CAMKIV. Among the synthesized compounds, the IC50 value (50% of ATPase activity) for compounds I (R = 2-nitrophenyl, R1 = H, R2 = 4-F; R = 4-chlorophenyl, R1 = 4-Me, R2 = H) was observed as 12.22 ¡À 1.12¦ÌM and 16.10 ¡À 1.30¦ÌM resp. The fluorescence binding and dot-blot assay further complements inhibitory potential, indicating a better binding affinity. These compounds were tested against human cancerous cells (HepG2) and observed a significant inhibition of cell viability, induced apoptosis and lowered tau-phosphorylation. In cell viability studies, the IC50 values for compounds I (R = 2-nitrophenyl, R1 = H, R2 = 4-F; R = 4-chlorophenyl, R1 = 4-Me, R2 = H) were 18.33 ¡À 1.12 and 26.22 ¡À 1.30¦ÌM resp. These results suggested that the compounds I (R = 2-nitrophenyl, R1 = H, R2 = 4-F; R = 4-chlorophenyl, R1 = 4-Me, R2 = H) are non-toxic to the normal cells and specifically inhibit the proliferation of cancerous cells.
ChemistrySelect published new progress about 4230-93-7. 4230-93-7 belongs to catalysis-chemistry, auxiliary class Alkenyl,Nitro Compound,Benzene,Ether, name is 1,2-Dimethoxy-4-(2-nitrovinyl)benzene, and the molecular formula is C10H11NO4, Safety of 1,2-Dimethoxy-4-(2-nitrovinyl)benzene.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia