Misra, Santosh K. published the artcileA dual strategy for sensing metals with a nano ‘pincer’ scavenger for in vitro diagnostics and detection of liver diseases from blood samples, Product Details of C6H20Cl2N4, the publication is Colloids and Surfaces, B: Biointerfaces (2015), 444-451, database is CAplus and MEDLINE.
This work presents a dual, non-invasive approach for the detection of elevated level of metals in patients with liver disease. A highly sensitive, small mol. ‘pincer’ scavenger was synthesized for the detection and quantification of copper in serum and systemically in vivo. For the in vitro diagnostics, the developed technique involves only a routine capillary blood sampling or venipuncture, removing the need for invasive biopsies. The organic scavenger mol. showed high specificity toward copper ions, with a detection sensitivity of 1.35 ¡Á 10-2 ¦Ìg/L in mouse serum. Furthermore, for the systemic detection of copper in the liver, a polymeric nanopincer has been designed and studied. The small mol. scavengers were stably incorporated into polymeric micelles via its long acyl chains and polymeric micelle proved to be a stable carrier when injected into mice i.v. The organic scavenger mol. was found to be highly fluorescent and specific toward Cu2+ and can potentially help ameliorate diseases regarding accretion of copper in certain vital organs. The strategy and the results provide a novel, non-invasive dual nanomedicine approach for the early detection and treatment of excessive metal deposits in the human organs.
Colloids and Surfaces, B: Biointerfaces published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Product Details of C6H20Cl2N4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia