van der Cruijsen, Elwin A. W. published the artcileBiomolecular DNP-Supported NMR Spectroscopy using Site-Directed Spin Labeling, Computed Properties of 215297-17-9, the publication is Chemistry – A European Journal (2015), 21(37), 12971-12977, database is CAplus and MEDLINE.
Dynamic nuclear polarization (DNP) has been shown to greatly enhance spectroscopic sensitivity, creating novel opportunities for NMR studies on complex and large mol. assemblies in life and material sciences. In such applications, however, site-specificity and spectroscopic resolution become critical factors that are usually difficult to control by current DNP-based approaches. We have examined in detail the effect of directly attaching mono- or biradicals to induce local paramagnetic relaxation effects and, at the same time, to produce sizable DNP enhancements. Using a membrane-embedded ion channel as an example, we varied the degree of paramagnetic labeling and the location of the DNP probes. Our results show that the creation of local spin clusters can generate sizable DNP enhancements while preserving the intrinsic benefits of paramagnetic relaxation enhancement (PRE)-based NMR approaches. DNP using chem. labeling may hence provide an attractive route to introduce mol. specificity into DNP studies in life science applications and beyond.
Chemistry – A European Journal published new progress about 215297-17-9. 215297-17-9 belongs to catalysis-chemistry, auxiliary class Linker,PROTAC Linker, name is 2-(2-((tert-Butyldimethylsilyl)oxy)ethoxy)ethan-1-amine, and the molecular formula is C11H15NO2, Computed Properties of 215297-17-9.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia