Nguyen, Hai Truong published the artcileIntermolecular and Intramolecular Friedel-Crafts Acylation of Carboxylic Acids using Binary Ionic Liquids: An Experimental and Computational Study, Recommanded Product: 2-Methylbenzoic acid, the publication is ChemistrySelect (2022), 7(2), e202103708, database is CAplus.
In this study, the desired products 2-RC6H4C(O)R1 (R = H, Br, Cl, F, Me; R1 = 4-methoxyphenyl, naphthalen-2-yl, 1H-indol-3-yl, etc.) were obtained at moderate to good yields under microwave irradiation for a short reaction time. The Friedel-Crafts cyclization of 4-phenylbutyric acid is more effective than 3-phenylpropionoic acid under the present method. The reaction mechanism is proposed by combining experiments with d. functional theory calculations, highlighting the critical role of ZnCl2, triflate anion (CF3COO-) in binary ionic liquids, and acidic conditions in accommodating a kinetic accessible pathway making the C-C bond.
ChemistrySelect published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Recommanded Product: 2-Methylbenzoic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia