Seeling, Andreas published the artcilePhysico-chemical, pharmacological, and toxicological properties of fomocaine metabolites, Category: catalysis-chemistry, the publication is Arzneimittel-Forschung (2001), 51(1), 7-17, database is CAplus and MEDLINE.
Fomocaine (4-[3-(4-phenoxymethylphenyl)-propyl]-morpholine, CAS 17692-39-6) is a highly effective local anesthetic of low toxicity. The drug, which causes no allergic response, was introduced in the German Extrapharmacopoeia (DAC). 14 Metabolites are formed after oral administration to rat and beagle dog. Less than 5 % fomocaine are excreted unchanged. The metabolites were synthesized and their physico-chem. properties were investigated. No metabolite caused a surface or conduction anesthesia with the exception of 2-hydroxyfomocaine (O/Se 4). After topical and parenteral administration irritation could not be observed All metabolites except O/Se 10 and O/Se 11 showed a lower toxicity than fomocaine. In both species O/Se 10 and O/Se 11 are formed only in a small amount and are detoxified by conjugation.
Arzneimittel-Forschung published new progress about 31719-76-3. 31719-76-3 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 4-(Phenoxymethyl)benzoic acid, and the molecular formula is C9H5ClO4S, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia