Klug, Stephan published the artcileEffects of valproic acid, some of its metabolites and analogs on prenatal development of rats in vitro and comparison with effects in vivo, COA of Formula: C10H20O2, the publication is Archives of Toxicology (1990), 64(7), 545-53, database is CAplus and MEDLINE.
Using a whole-embryo culture system, valproic acid (VPA) and some of its metabolites and analogs were tested for their teratogenic effects. With regard to embryonic growth, development, and abnormality rate, the tested compounds showed a wide range of teratogenic potency in vitro. Pregnant rats were also treated s.c. on day 10 of gestation with 2 ¡Á 330 mg VPA/kg or 2 ¡Á 400 mg 2-en-VPA/kg. Evaluation of the embryos was performed on day 11.5 of gestation, corresponding to the in vitro experiments VPA showed a high potential to induce abnormal development in vivo as well as in vitro, whereas 2-en-VPA was inactive. The predictive value of an in vitro test system for the detection of embryotoxic effects, such as validation and significance of pharmacokinetic data, are discussed.
Archives of Toxicology published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, COA of Formula: C10H20O2.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia