Xie, Jianing published the artcilePd-catalyzed stereoselective tandem ring-opening amination/cyclization of vinyl ¦Ã-lactones: access to caprolactam diversity, Formula: C11H10O3, the publication is Chemical Science (2020), 11(33), 8839-8845, database is CAplus and MEDLINE.
A stereoselective amination/cyclization cascade process was developed that allowed for the preparation of a series of unsaturated and substituted caprolactam derivatives I [R = Ph, 3,5-di-MeC6H3, 2-naphthyl, etc.; R1 = Ph, Bn, CH(Ph)2, etc.; R2 = H, Me, R3 = CH2, C=CH2, CHPh] in good yields. This conceptually novel protocol took advantage of the easy access and modular character of vinyl ¦Ã-lactones that could be prepared from simple precursors. Activation of the lactone substrate in the presence of a suitable Pd precursor and newly developed phosphoramidite ligand offers a stereocontrolled ring-opening/allylic amination manifold under ambient conditions. The intermediate (E)-configured ¦Å-amino acid could be cyclized using a suitable dehydrating agent in an efficient one-pot, two-step sequence. This overall highly chemo-, stereo- and regio-selective transformation streamlined the production of a wide variety of modifiable and valuable caprolactam building blocks in an operationally attractive way.
Chemical Science published new progress about 15732-75-9. 15732-75-9 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ketone, name is 2-Methylene-4-oxo-4-phenylbutanoic acid, and the molecular formula is C9H5ClO4S, Formula: C11H10O3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia