Li, Daichun published the artcileSynthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents, Recommanded Product: Fmoc-Pro-OH, the publication is Marine Drugs (2022), 20(3), 158, database is CAplus and MEDLINE.
In this paper, eight new galaxamide analogs (Z-1?Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analog Z-6 displayed broad spectrum cytotoxic activity toward each tested cell line with IC50 values of 1.65 ¡À 0.30 (MCF-7), 2.91 ¡À 0.17 (HepG2), 4.59 ¡À 0.27 (MD-MBA-231), 5.69 ¡À 0.37 (Hela), and 5.96 ¡À 0.41 (A549) ¦Ìg/mL, resp. The galaxamides Z-3 and Z-6 induced concentration-dependent apoptosis of the MCF-7 cells after 72 h as evaluated by the flow cytometry experiment The results showed that these compounds could induce MCF-7 cell apoptosis by arresting the G0/G1 phase of the cell cycle and finally achieving the effect of inhibiting the proliferation of MCF-7 cells.
Marine Drugs published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C20H19NO4, Recommanded Product: Fmoc-Pro-OH.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia