Zhu, Ya published the artcileStructural basis of FPR2 in recognition of A¦Â42 and neuroprotection by humanin, HPLC of Formula: 63-68-3, the publication is Nature Communications (2022), 13(1), 1775, database is CAplus and MEDLINE.
Formyl peptide receptor 2 (FPR2) has been shown to mediate the cytotoxic effects of the ¦Â amyloid peptide A¦Â42 and serves as a receptor for humanin, a peptide that protects neuronal cells from damage by A¦Â42, implying its involvement in the pathogenesis of Alzheimers disease (AD). However, the interaction pattern between FPR2 and A¦Â42 or humanin remains unknown. Here we report the structures of FPR2 bound to Gi and A¦Â42 or N-formyl humanin (fHN). Combined with functional data, the structures reveal two critical regions that govern recognition and activity of A¦Â42 and fHN, including a polar binding cavity within the receptor helical bundle and a hydrophobic binding groove in the extracellular region. In addition, the structures of FPR2 and FPR1 in complex with different formyl peptides were determined, providing insights into ligand recognition and selectivity of the FPR family. These findings uncover key factors that define the functionality of FPR2 in AD and other inflammatory diseases and would enable drug development.
Nature Communications published new progress about 63-68-3. 63-68-3 belongs to catalysis-chemistry, auxiliary class Natural product, name is (S)-2-Amino-4-(methylthio)butanoic acid, and the molecular formula is C7H8O3, HPLC of Formula: 63-68-3.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia