Angewandte Chemie, International Edition published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.
Lovelock, Sarah L. published the artcilePhenylalanine ammonia lyase catalyzed synthesis of amino acids by an MIO-cofactor independent pathway, COA of Formula: C9H7NO4, the publication is Angewandte Chemie, International Edition (2014), 53(18), 4652-4656, database is CAplus and MEDLINE.
Phenylalanine ammonia-lyases (PALs) belong to a family of 4-methylideneimidazole-5-one (MIO) cofactor-dependent enzymes which are responsible for the conversion of L-phenylalanine into trans-cinnamic acid in eukaryotic and prokaryotic organisms. Under conditions of high NH3 concentration, this deamination reaction is reversible and hence there is considerable interest in the development of PALs as biocatalysts for the enantioselective synthesis of non-natural amino acids. Here, the discovery of a previously unobserved competing MIO-independent reaction pathway, which proceeds in a non-stereoselective manner and results in the generation of both L– and D-phenylalanine derivatives, is described. The mechanism of the MIO-independent pathway is explored through isotopic-labeling studies and mutagenesis of key active site residues. The results obtained were consistent with amino acid deamination occurring by a stepwise E1cB elimination mechanism.
Angewandte Chemie, International Edition published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, COA of Formula: C9H7NO4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia