Tong, Xue published the artcileNickel-catalyzed defluorinative alkylation of C(sp2)-F bonds, Safety of 4,4′-Dimethyldiphenyl, the publication is Organic Chemistry Frontiers (2021), 8(16), 4533-4542, database is CAplus.
The direct conversion of a C(sp2)-F bond into the corresponding C(sp2)-C(sp3) bond using Al(alkyl)3 as the coupling partner under nickel catalysis to gave compounds ArR [Ar = 4-MeOC6H4, 4-PhC6H4, 2-naphthyl, etc.; R = Me, Et] and R1HC=CR2R3 [R1 = 4-MeOC6H4, 4-PhC6H4, phenethyl, etc.; R2 = Me, Et; R3 = H, Me, Et] was reported. Intriguingly, aryl fluorides, alkenyl monofluorides and alkenyl gem-difluorides were viable electrophiles in this transformation, constituting the notable feature of this protocol. The success of this chemoselective method relied on the fluorophilicity of the employed aluminum reagent that functions as both the Lewis acid for the activation of the challenging C-F bond and the corresponding alkylating partner. Successful application of this strategy to the late-stage C-F alkylation of fluorinated drug analog was also demonstrated. This method represented another important example of using challenging C-F bonds as alternative electrophiles.
Organic Chemistry Frontiers published new progress about 613-33-2. 613-33-2 belongs to catalysis-chemistry, auxiliary class Benzene, name is 4,4′-Dimethyldiphenyl, and the molecular formula is C6H13NO2, Safety of 4,4′-Dimethyldiphenyl.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia