Kim, Kyeojin published the artcileGlucal-conjugated sterols as novel vascular leakage blocker: Structure-activity relationship focusing on the C17-side chain, Related Products of catalysis-chemistry, the publication is European Journal of Medicinal Chemistry (2014), 184-194, database is CAplus and MEDLINE.
A series of glucal-conjugated sterols as novel vascular leakage blocker were identified through design, synthesis and biol. evaluation. In addition, the structure-activity relationship (SAR) of the glucal-conjugated sterols focusing on the C17-side chain was also established. The sterol analogs linked with the rigid C17-side chain side chains exhibited potent cell survival activities. In particular, ((2R,3S)-3-Acetoxy-6-((3S,10R,13S,17S)-17-((E)-1-(cyclopentyloxyimino)ethyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxy)3,6-dihydro-2H-pyran-2-yl)methyl acetate, which possesses a cyclopentyl oxime moiety, was shown to have excellent pharmacol. effects on retinal vascular leakage in a diabetic mouse model.
European Journal of Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia