Funnell, Richard A. published the artcileThree reactions leading to isomeric 2-(N,N-disubstituted amino)thiazol-5-yl ketones, Application In Synthesis of 6972-05-0, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1987), 2311-15, database is CAplus.
N-Imidoyl-N,N-disubstituted thioureas PhNHCR:NCSR1 (R = CMe3, Ph, 4-MeOC6H4, 4-ClC6H4, 2-thienyl, R1 = NMe2, NPhMe, pyrrolidino, piperidino, morpholino, hexahydroazepino) react with ¦Á-halo ketones R2COCH2R3 (I, R2 = Me, R3 = Cl; R2 = Me, CMe3, Ph, 4-ClC6H4, 4-MeOC6H4, 4-O2NC6H4, Me2CH, R3 = Br) in the presence of Et3N to give the expected 2-(N,N-disubstituted amino)thiazol-5-yl ketones II in high yield. The corresponding reactions of N-acyl-N,N-disubstituted thioureas RCONHCSR1 with I lead to mixtures of II and III, which arise from rearrangement between cyclic intermediates. Mixtures of II and III are also formed by treating N,N-disubstituted thioureas R1CSNH2 with 2-bromo-1,3-diketones RCOCHBrCOR2. The mixtures from the second and third routes contain the same products but in significantly different proportions. A mechanistic scheme which accounts for the main findings was developed. Characteristic mass spectral fragmentation patterns were particularly useful in identifying the substituents at positions 4 and 5 of the thiazole ring.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, Application In Synthesis of 6972-05-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia