Forlani, Luciano published the artcileIntermediates in the halogenation of some 2-aminothiazoles, SDS of cas: 6972-05-0, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1978), 1169-71, database is CAplus.
Halogenations (Cl, Br, 0¡ã) of aminothiazoles I (R1 = R2 = H, RR3 = bond) (R4 = H, R5 = H, Me2CHCH2, PhCH2; R4 = R5 = Me) in MeOH, EtOH, H2O, or (HOCH2)2 occurred regio- and stereospecifically to give the corresponding thiazoline hydrohalides I.HR1 (R = R2 = H) (R1 = Cl, Br; R3 = OMe, OEt, OH, OCH2CH2OH) (80-95%). E.g., 95% I.HR1 (R = R2 = R4 = R5 = H, R1 = Br, R3 = OEt) was obtained by bromination of 2-aminothiazole in EtOH. The mechanism of the reaction is discussed. The halothiazoline products were converted to the corresponding 5-halothiazoles I (RR3 = bond, R1 = halo, R2 = H) on heating a few h at ?70¡ã.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 6972-05-0. 6972-05-0 belongs to catalysis-chemistry, auxiliary class Thiourea,Amine,Aliphatic hydrocarbon chain,Amide, name is 1,1-Dimethylthiourea, and the molecular formula is C3H8N2S, SDS of cas: 6972-05-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia