Chapman, Astrid G. published the artcileAcute anticonvulsant activity of structural analogs of valproic acid and changes in brain GABA and aspartate content, Computed Properties of 3115-28-4, the publication is Life Sciences (1983), 32(17), 2023-31, database is CAplus and MEDLINE.
Ten analogs of valproic acid (substituted butyric, pentanoic and hexanoic acids) were tested for anticonvulsant activity against audiogenic seizures in DBA/2 mice. There is a consistent correlation between the structure of these branched-chain fatty acids and their anticonvulsant potency, the larger mols. being the more active. There is also a strong correlation between the anticonvulsant potency of these compounds and their ability to reduce cerebral aspartate??[56-84-8] levels. Cerebral GABA??[56-12-2] levels are elevated by most, but not all, of the actively anticonvulsant valproate analogs.
Life Sciences published new progress about 3115-28-4. 3115-28-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is 2-Butylhexanoic acid, and the molecular formula is C10H20O2, Computed Properties of 3115-28-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia