Febles, Martin published the artcileSynthesis and biological evaluation of crown ether acyl derivatives, Safety of 2-(3-(Benzyloxy)phenyl)acetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(22), 5591-5593, database is CAplus and MEDLINE.
A set of crown Et acyl derivatives based on 18-crown-6 moiety was synthesized and evaluated for biol. activity. In vitro antiproliferative profiling demonstrated significant activities against HBL-100, HeLa, SW1573 and WiDr human cell lines. The most active compound exhibited GI50 values in the range of 3.7-5.6 ¦ÌM. Antimicrobial evaluation showed that three polyaromatic compounds were active against Staphylococcus aureus (MIC90 values from 8.3 ¦ÌM to 50 ¦ÌM), whereas a (decyloxy)benzene substitution exhibited moderate activity against Candida albicans (MIC90 values 36 ¦ÌM). According to SAR evaluation, the size of the crown ether and the acyl side chain had a significant effect on the bioactivity. Aromatic moieties close to the acyl group led to improved bioactivity as exemplified by some of the tested compounds These results provide further evidence on the potential of crown Et structure as a scaffold for developing new biol. probes and lead candidates for drug development.
Bioorganic & Medicinal Chemistry Letters published new progress about 1860-58-8. 1860-58-8 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Ether, name is 2-(3-(Benzyloxy)phenyl)acetic acid, and the molecular formula is C15H14O3, Safety of 2-(3-(Benzyloxy)phenyl)acetic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia