Abrahami, Renata A. published the artcileA de novo synthetic route to 1,2,3,4-tetrahydroisoquinoline derivatives, Application In Synthesis of 421-49-8, the publication is Synlett (2018), 29(15), 2066-2070, database is CAplus.
A novel synthetic approach was developed for the construction of the 1,2,3,4-tetrahydroisoquinoline framework, e.g. I (R1 = Et, CHF2CH2, CF3CH2, CF3CHMe, PhCH2, etc.; R2 = H, Br), possessing varied functions. The synthetic strategy is based on oxidative ring opening of the corresponding indandiols, e.g. II, followed by double reductive amination of the dicarbonyl intermediates with various primary alkyl- or fluoroalkylamines R1NH2.
Synlett published new progress about 421-49-8. 421-49-8 belongs to catalysis-chemistry, auxiliary class Trifluoromethyl,Fluoride,Amine,Aliphatic hydrocarbon chain, name is 1,1,1-Trifluoropropan-2-amine, and the molecular formula is C3H6F3N, Application In Synthesis of 421-49-8.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia