Tetrahedron published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.
Rowles, Ian published the artcileEngineering of phenylalanine ammonia lyase from Rhodotorula graminis for the enhanced synthesis of unnatural L-amino acids, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid, the publication is Tetrahedron (2016), 72(46), 7343-7347, database is CAplus.
Phenylalanine ammonia lyase (PAL) catalyzes the reversible non-oxidative deamination of phenylalanine to trans-cinnamic acid and ammonia. Analogs of L-phenylalanine are incorporated as pharmacophores in several peptidomimetic drug mols. and are therefore of particular interest to the fine chem. industry. PAL from Rhodotorula graminis (RgrPAL) has shown an ability to accept analogs of L-phenylalanine. Our aim was to increase enzymic activity with directed evolution towards a specific non-natural substrate through the cloning and over-production of PAL in Escherichia coli. The identified variants of RgrPAL with significantly showed more catalytic efficient compared to the wild-type enzyme. These variants were used in a preparative scale biotransformation resulting in a 94% conversion to L-4-Br-phenylalanine (>99% ee).
Tetrahedron published new progress about 1772-76-5. 1772-76-5 belongs to catalysis-chemistry, auxiliary class Benzenes, name is (E)-3-(3-Nitrophenyl)acrylic acid, and the molecular formula is C9H7NO4, Recommanded Product: (E)-3-(3-Nitrophenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia