Vastakaite, Greta published the artcilePeptide-Catalyzed Stereoselective Conjugate Addition Reaction of Aldehydes to C-Substituted Maleimides, HPLC of Formula: 71989-31-6, the publication is Chemistry – A European Journal (2022), 28(18), e202200215, database is CAplus and MEDLINE.
Catalytic stereoselective additions with maleimides I (R = C6H5, 4-ClC6H4, 2-BrC6H4, etc.) are useful one-step reactions to yield chiral succinimides II (R1 = CH3, CH2CH3, CH2C6H5, etc.), mols. that are widespread among therapeutically active compounds but challenging to prepare when the maleimide is C-substituted. The tripeptide H-Pro-Pro-Asp-NHC12H25 as a catalyst for conjugate addition reactions between aldehydes R1CH2CHO and C-substituted maleimides I to form succinimides II with three contiguous stereogenic centers in high yields and stereoselectivities has been described. The peptidic catalyst is so chemoselective that no protecting group is needed at the imide nitrogen of the maleimides I. Derivatization of the succinimides was straightforward and provided access to chiral pyrrolidines, lactones e.g., III, and lactams. Kinetic studies, including a Hammett plot, provided detailed insight into the reaction mechanism.
Chemistry – A European Journal published new progress about 71989-31-6. 71989-31-6 belongs to catalysis-chemistry, auxiliary class Amino acide derivatives,pyrrolidine, name is Fmoc-Pro-OH, and the molecular formula is C6H10N2, HPLC of Formula: 71989-31-6.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia