Kuboyama, Takeshi published the artcileStoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido([18F]fluoromethyl)benzenes by Cu-catalyzed Huisgen reaction, Synthetic Route of 17351-62-1, the publication is Bioorganic & Medicinal Chemistry (2011), 19(1), 249-255, database is CAplus and MEDLINE.
A novel method for 18F-radiolabeling of oligodeoxynucleotides (ODNs) by a Cu-catalyzed Huisgen reaction has been developed by using the lowest possible amount of the precursor biomol. for the realization of stoichiometry-oriented PET (positron emission tomog.) chem. Under the optimized cyclization conditions of p- or m-azido([18F]fluoromethyl)benzene and alkyne-substituted ODN (20 nmol) at 40 ¡ãC for 15 min in the presence of CuSO4, TBTA [tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine], and sodium ascorbate (2:1:2), the synthesis of 18F-labeled ODNs with sufficiently high radioactivities of 2.1-2.5 GBq and specific radioactivities of 1800-2400 GBq/¦Ìmol have been accomplished for use in animal and human PET studies.
Bioorganic & Medicinal Chemistry published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C17H37NO3, Synthetic Route of 17351-62-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia